完全可以合理推论，阿扎胞苷对kras g12c的疗效不会比Sotorasib差
1、《Computational insights into KRAS G12C inhibition: exploring possible repurposing of Azacitidine and Ribavirin》“Azacitidine and Ribavirin, exhibited substantial binding affinities of -8.7 and -8.3 kcal/mol, respectively.”
阿扎胞苷、利巴韦林对 kras g12c 的结合亲和力是 -8.7 and -8.3 kcal/mol。
2、《Establishing the Role of Iridoids as Potential Kirsten Rat Sarcoma Viral Oncogene Homolog G12C Inhibitors Using Molecular Docking; Molecular Docking Simulation; Molecular Mechanics Poisson-Boltzmann Surface Area; Frontier Molecular Orbital Theory; Molecular Electrostatic Potential; and Absorption, Distribution, Metabolism, Excretion, and Toxicity Analysis》
Sotorasib (dock score: -9.1 kcal/mol).
kras g12c 已经上市的靶向药 Sotorasib 跟kras g12c的结合亲和力是 -9.1 kcal/mol.
3、阿扎胞苷只比 Sotorasib 低一点点；但是阿扎胞苷注射药 ，皮下注射给药为主，也有静脉给药的用法；Sotorasib是口服药；阿扎胞苷的生物利用度比Sotorasib要高很多；因此完全可以合理推论，阿扎胞苷对kras g12c的疗效不会比Sotorasib差。
阿扎胞苷分子量很小只有 244.2，也不用担心不入脑的问题。
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