发给老马备查:6 v& q1 y; T7 p* _) U% j2 _ C& R
滴水察海(69304838) 15:23:23
; Q2 h+ H( s& u: J/ a- z7 S- W老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
4 |+ ~2 z% N; q: U6 V7 ?吉非替尼和S-1连用的依据
$ h4 A9 E3 E4 w+ A6 M. zGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro., |4 B) `0 C' e- G5 n. s* A
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达& l: H9 N1 ?. ~
这样是不是推理出,耐药后,可以用S-1和培美了?1 b, D, N" U* a) `& F
结论:
# r! L* H( n2 ]1 L D1 |3 r; m2 ` l如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |