发给老马备查:
0 l. P* n4 _) b2 B& B. O/ |滴水察海(69304838) 15:23:23
/ i9 z- b1 A# m5 g7 D. O: n老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱0 O, m1 t6 W7 [! L- L0 |! a
吉非替尼和S-1连用的依据. ]" t, C" \8 B/ n
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
" S# N8 F% e1 O q是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
# i' z; q& p, b: i3 w这样是不是推理出,耐药后,可以用S-1和培美了?
9 X ^ m- J3 K Q5 \结论:
, \6 g. a+ U: y7 V$ G0 a如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |