发给老马备查:
2 a9 w+ Z( i7 q0 ~4 Y滴水察海(69304838) 15:23:23 G! c' `. O+ k; z* d" W
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱: a% e1 i7 X$ o8 V
吉非替尼和S-1连用的依据
' M2 I( R6 W' R: @: HGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
9 H/ z, Z1 H6 ~是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达8 B, I$ L1 C8 v6 R6 A
这样是不是推理出,耐药后,可以用S-1和培美了?: I. { @9 s. x% |" `: _7 Y! J
结论:
) u A( y: H# X6 l, c' k如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |