• 患者服务: 与癌共舞小助手
  • 微信号: yagw_help22

QQ登录

只需一步,快速开始

开启左侧

还没做过化疗,EGFR是野生型的病友一定要去做ALK的检测

  [复制链接]
186557 161 godblessmymum 发表于 2012-6-16 23:11:32 |
健康活着  小学五年级 发表于 2012-9-18 18:53:34 | 显示全部楼层 来自: 广东广州
落花无意  小学六年级 发表于 2012-9-22 15:56:39 | 显示全部楼层 来自: 上海
请问,肺鳞癌,只做过一次化疗,骨髓抑制严重,后吃特罗凯4个月基本无效,可以参加实验组吗?
godblessmymum  大学二年级 发表于 2012-9-24 20:13:39 | 显示全部楼层 来自: 上海虹口区
不可以了,要没做过任何治疗的,包括化疗和靶向药
老马  博士一年级 发表于 2012-10-14 22:18:42 | 显示全部楼层 来自: 浙江温州
Concomitant EGFR mutation and EML4-ALK gene fusion in non-small cell lung cancer.  Print this page  
- }. C9 @9 g2 ^" m3 D
& R. @4 r3 M* n2 Z( W3 r) H& c0 \5 d  U* o/ H/ N. O: N9 Z3 F
Sub-category:& @: ]# ~+ a5 V/ i- i/ \! N7 m9 ?$ L. `
Molecular Targets # J! ]3 \) g; S& q8 g# r& @
- v/ `$ s0 Z+ X# X: Z0 k1 Y* h0 u
$ h) N# E+ ^& M; A- h
Category:
8 Y6 v0 w' y+ j, C; x3 K" b. [* jTumor Biology
4 V! p7 r* O  N3 E3 x/ ~
; Z2 b$ ?+ l7 x: J% B
1 k4 T& Y8 m' R! m0 [" _: HMeeting:6 w) l* }; Q" x* Y2 J
2011 ASCO Annual Meeting ! ?8 B! M8 F1 v) A: k/ n
/ @) V( S9 u3 k0 z/ Z

1 |0 M! w8 R6 ?7 ?' Q5 g1 {Session Type and Session Title:
+ S8 M1 F- F8 X2 B2 v, rPoster Discussion Session, Tumor Biology + b% s7 ~& n$ E" a8 E2 @! Y3 h
. K0 ^) k0 V& L: @9 O* M
/ s# u; V; i1 Z7 y; L( @" M
Abstract No:+ c( [4 ~: K, F, W
10517 % u: M- G$ G1 u

3 \; ?& U$ Z! u+ ^
# ?% n/ U: h9 G, F8 ]1 UCitation:% T: i1 z4 {% @* l4 n
J Clin Oncol 29: 2011 (suppl; abstr 10517) $ r& D1 M, U# j  G; q# Z) a/ E/ N

% Q0 z7 K2 e# J! N1 L- \* c( B0 M) G! T8 r) O
Author(s):4 U) g( |. g( R) B* q. V; b
J. Yang, X. Zhang, J. Su, H. Chen, H. Tian, Y. Huang, C. Xu, Y. L. Wu; Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China; Guangdong Lung Cancer Institute, Medical Research Center of Guangdong General Hospital, Guangzhou, China; Guangdong Lung Cancer Institute, Guangzhou, China; Guangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou, China 1 T0 n% l  ^; K- N
/ g. t4 x4 F4 s' b- O2 S

+ y, g& I2 L$ Y1 K9 B( `1 ~2 {1 Z8 ~6 _/ p# n
Abstracts that were granted an exception in accordance with ASCO's Conflict of Interest Policy are designated with a caret symbol (^) here and in the printed Proceedings.4 P: G: s" D6 d7 h

+ G3 u% ~! _5 Z8 z6 H, D6 kAbstract Disclosures
! H: ?+ l- n$ \" [$ l( ~
- S6 e- U4 b+ aAbstract:) L1 Z1 o- I( d
. C8 F: w# S. M' i$ }/ k
4 W" K! ?' z9 ]7 j6 R+ _
Background: The fusion of the anaplastic lymphoma kinase (ALK) with the echinoderm microtubule-associated protein-like 4 (EML4) and epidermal growth factor receptor (EGFR) mutations are considered mutually exclusive. Advanced non-small cell lung cancer (NSCLC) patients with EML4-ALK did not benefit from EGFR tyrosine kinase inhibitors (TKIs). Methods: Multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) followed by sequencing was performed for EML4-ALK fusion status detection. EGFR and KRAS mutations were determined by direct DNA sequencing. Positive results of EML4-ALK fusion were also confirmed by RACE-coupled PCR sequencing. Results: From April 2010 to January 2011, 412 patients (398 with NSCLC; 14 with SCLC) were tested for mutation status of EGFR, KRAS and EML4-ALK respectively. Frequency of EML4-ALK fusion was 10.6% (42/398) in NSCLC patients. No patients with SCLC were found to have positive EML4-ALK fusion. Frequency of concomitant EGFR and EML4-ALK gene mutations was 1.0% (4/398) in NSCLC patients, and their variants of EML4-ALK gene mutations were Variant 1 (3 patients) and Variant 6 (1 patient); being never smokers, all of them were diagnosed with advanced (3 with stage †W and 1 with stage IIIB) adenocarcinoma harbouring wild type KRAS. Two female stage †W patients with double gene mutations (1 with L858R and Variant 1; 1 with exon19 deletion and Variant 6) received first-line gefitinib which is one kind of EGFR TKIs and achieved partial response. Conclusions: Though being rare events, NSCLC patients harbouring concomitant EGFR mutation and EML4-ALK gene fusion are sensitive to first-line EGFR TKIs. Whether they could also benefit from ALK inhibition after failure to EGFR TKIs warranted further investigation.9 c. [9 Q) H- X
" x: O  L( O+ O. }8 c
8 e3 G" L+ R- ^, f- c
个人公众号:treeofhope
累计签到:8 天
连续签到:1 天
[LV.3]与爱熟人
一只白杨  大学一年级 发表于 2012-11-15 17:48:59 | 显示全部楼层 来自: 广东广州
由吴一龙教授牵头的A80810029临床试验上周启动,初诊未治疗的晚期肺腺癌患者检测到ALK阳性,可参加一线crizotinib 对比力比泰+卡铂的临床研究,药物全部免费,即使分配到力比泰组,疾病进展之后可免费获得crizotinib.
boeun  小学四年级 发表于 2012-11-18 16:37:21 | 显示全部楼层 来自: 福建泉州
没有手术,只化疗过,现吃靶向药,未突变,alk未测,有机会入组吗?
godblessmymum  大学二年级 发表于 2012-11-18 23:23:21 | 显示全部楼层 来自: 上海杨浦区
boeun 发表于 2012-11-18 16:37
8 o0 Y& @: H" C9 w没有手术,只化疗过,现吃靶向药,未突变,alk未测,有机会入组吗?

& i* V* ]+ E6 n! _$ q化疗过的没机会了
helpU  高中三年级 发表于 2012-12-3 21:04:24 | 显示全部楼层 来自: 北京
平安! 发表于 2012-7-20 11:20
+ m5 x; ~# d/ S, O6 t易瑞沙、特罗凯有效的病人基本上可以断定ALK(-)。极其罕见EGFR、ALK同时突变的。
* \+ k0 L% Q# U4 P$ w* u  v7 IALK一个指标医院要900多 ...

9 F3 Y) W* k5 b平安,真的没有希望吗?我弟弟虽然特罗凯有效,但是EGFR是野生型,不是突变啊。有没有必要去检测ALK呢?4 m8 i. s! j: G2 W5 a6 \! q
1 C5 P% Z5 d& [3 c  P
现在病情进展,快没招儿了。
294170420  初中二年级 发表于 2012-12-4 22:04:38 | 显示全部楼层 来自: 浙江丽水
好像想加入挺困难的
wdc2482  小学六年级 发表于 2012-12-19 18:47:22 | 显示全部楼层 来自: 青海西宁
小地方没条件做啊

举报 使用道具

回复 支持 0 反对 1

发表回复

您需要登录后才可以回帖 登录 | 立即注册

本版积分规则

  • 回复
  • 转播
  • 评分
  • 分享
帮助中心
网友中心
购买须知
支付方式
服务支持
资源下载
售后服务
定制流程
关于我们
关于我们
友情链接
联系我们
关注我们
官方微博
官方空间
微信公号
快速回复 返回顶部 返回列表